Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration

ALAIN01—Alemtuzumab in autoimmune inflammatory neurodegeneration: mechanisms of action and neuroprotective potential

BACKGROUND Alemtuzumab (Lemtrada®) is a newly approved therapeutic agent for relapsing-remitting multiple sclerosis (RRMS). In previous phase II and III clinical trials, alemtuzumab has proven superior efficacy to subcutaneous interferon beta-1a concerning relapse rate and disability progression with unprecedented durability and long-lasting freedom of disease activity. The humanized monoclonal...

Neuroprotective strategies against calpain-mediated neurodegeneration

Calpains are calcium-dependent proteolytic enzymes that have deleterious effects on neurons upon their pathological over-activation. According to the results of numerous studies to date, there is no doubt that abnormal calpain activation triggers activation and progression of apoptotic processes in neurodegeneration, leading to neuronal death. Thus, it is very crucial to unravel all the aspects...

Putative neuroprotective compounds in in vitro models of dopaminergic neurodegeneration

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Mechanisms of Neuroprotection Underlying Physical Exercise in Ischemia – Reperfusion Injury

Evaluation of neuroprotective effects of cobalamin (vitamin B12) in Parkinson's disease - Investigation of molecular mechanisms

‌Background & objectives: Parkinson's disease is one of the most common neurodegenerative diseases that its prevalence has increased in recent years. Although many efforts have been made to treat this disease, so far, no therapeutic approach has been found that can stop the destruction of dopaminergic cells in the substantia nigra. The aim of the present study was to investigate the effect of v...